| Description: |
For performance testing of models and tools for
human and environmental risk assessment of nanomaterials selected in the caLIBRAte project, appropriate data sets are needed. Several European and national projects have produced an enormous amount of data on hazard, release and exposure of nanomaterials,
including EU-projects NANoREG, NANOSOLUTIONS, MARINA and NANOGENOTOX, that may be of significant use for assessment.
A thorough analysis, comparing the available information on 34 reference nanomaterials with the input parameters required by the models, was completed within caLIBRAte. Complete datasets were identified, as were data gaps. The latter were identified with the goal to generate new data
within the project to fill these gaps.
A detailed gap analysis on information for physico-chemical characteristics, human toxicity and ecotoxicity for different nanoforms of specific reference nanomaterials was carried out using the data from the caLIBRAte database (data from projects MARINA, NANoREG, NANOGENOTOX, NanoTest) plus additional data from projects EnvNano, nanoFATE, NanoMILE and the NanoETox dataset, plus data available from OECD. The information on nanomaterials from within those data sets was matched to the identified input parameters of the selected models for human and environmental risk assessments along the different stages of the Cooper StageGate model: Guidenano, NanoSafer, LICARA, SUNDS, Swiss Precautionary Matrix (SPM), SimpleBox4Nano, Mend2Nano, NanoQSAR and SSWD. |